About My Guest My guest for this episode is Dr. Dietrich Klinghardt. I shared Dietrich Klinghardt MD's professional bio in episode #15, and for this introduction, I am going to be less formal and speak from personal experience. I met Dr. Klinghardt in January 2006 shortly after my own Lyme diagnosis in July 2005. I was in the front row of his conference probably asking more questions than he would have liked, but it was the start of my journey with his work, and I was beyond excited and hopeful. I then became a patient and worked with him for several years and was able to regain my health through the implementation of not oAbout My Guest My guest for this episode is Dr. Theo Theoharides. Dr. Theo Theoharides, PhD, MD has studied the regulation of mast cell activation and its role in neuroinflammatory disease for over 30 years. He holds a Masters in Neuroimmunology, a PhD in Pharmacology, and an MD from Yale University. He was the first to report that mast cells can secrete specific mediators selectively without degranulation, regulate blood-brain-barrier permeability, stimulate microglia, be activated by corticotropin-releasing hormone (CRH) secreted under stress to release VEGF selectively, be activated by synergistic action of CRH and neurotensin, be activated by IL-33 and substance P synergistically to secrete the pro-inflammatory cytokine TNF, secrete mitochondrial DNA extracellularly that is mistaken by the body as a pathogen resulting in inflammatory reactions, and communicate with microglia and are involved in inflammation of the brain. He discovered that mast cells are inhibited by certain natural flavonoids, especially luteolin and tetramethoxyluteolin. He has published over 400 peer-reviewed papers and is in the top 5% of authors cited in pharmacological and immunological journals. He is the developer of the well-known liposomal mast cell blocking nutritional supplement known as NeuroProtek and several other products. Key Takeaways What is the difference between mastocytosis and mast cell activation syndrome (MCAS)? What are some conditions where MCAS may play a role? What are some of the common symptoms of mast cell activation? How do temperature or season changes impact symptoms? What are the common triggers of MCAS? What role does stress play in triggering mast cells? What are the best ways to approach testing for MCAS? Can Lyme disease itself be a trigger for mast cells? What is the link between MCAS and brain fog? What role does leaky gut play in MCAS? How do EMFs impact mast cells? What treatment options might be appropriate in MCAS? Connect With My Guest http://www.mastcellmaster.com Related Resources Algonot (NeuroProtek) My Mystery Symptoms and Mast Cells Video Lecture with Dr. Theo Donate to Support Dr. Theo's Work Interview Date January 29, 2018 nly his treatment protocols, but his healing framework. To this day, no other person has impacted my understanding of health and wellness as much as Dr. Klinghardt, and I will be forever grateful. Key Takeaways What conditions may have a retroviral component? Are retroviruses the deeper core issue? How are retroviruses encountered? What tests can be done to explore retroviruses? What is the connection between retroviruses and the cell-danger response? What role do EMRs, glyphosate, and aluminum play in the activation of retroviruses? What are some of the key retrovirus treatment options? What is the connection between EMR and mold illness from water-damaged buildings? What role might breast implants play in impacting recovery? What are the latest perspectives on rope worms? How commonly do stem cells result in significant improvement? Do DMPS, DMSA, and EDTA still play a role in patient recovery? Connect With My Guest http://sophiahi.com Related Resources The Role of Retroviruses in Chronic Illness – A Clinician’s Perspective Safe Uses of Suramin and Other Anti-Retroviral Approaches Interview Date July 2, 2018 Disclosure